Assuming your system of choice includes alignment in anywhere from three to nine flavors, how big a role does alignment play in your campaign?
Back in my High School years, I used to plot that out on a grid for each PC, much like the DMG suggested. What a fucking waste of time. With the exception of any Paladins in the party, the average PC could at best be defined as Chaotic Selfish. Paladins were Lawful Stupid, Deaf and Blind.
These days I mostly hand wave it "So, you take the Orc hostage, put him tied up in a mining cart, pour oil on him, light him and send him screaming and flaming down the tracks? Neutral Good you say you are? You gave him a choice: talk and live or stay silent and burn and the choice was his? This would have been fair game on 24 with Jack Baur? Sigh. Lets move on to the mobile flaming orc."
Do we need alignment? Is good and evil a matter of perspective? Should alignment be kept but redefined?