I have some experience running GURPS 20 years ago, and I'm looking closely at Savage Worlds (and plan on rereading the rules to both as time permits). Yes, I'm leaving Basic Roleplaying / RuneQuest / Legend off the list as I wait to see what the latest edition of RQ will offer.
The game plan (such as it is) is to run a OSR (D&D clone) and a non-OSR game, and alternate the system on a weekly basis. It would keep the systems from getting old, and always give me two weeks to get things ready for the next game of the same type.
I know GURPS is the heavier system (and looking at Conan: Beyond Thunder Dome, I'm reminded how crunchy the system is). Both GURPS and Savage Worlds have a huge amount of setting books. I'm actually reading Beasts & Barbarians for Savage Worlds this weekend, and it look like a fun Swords & Sorcery setting for S&W.
I'm open to input. I'll even look at other systems if the argument is solid ;)