So, for my Sci-Fi flavored S&W project, I'm thinking something along the lines of Firefly, mixing in some Cthulhu Mythos with possibly a nod to the Hellblazer comic book of the 80's.
Darker than the average sci-fi RPG. Of course, these are all broad brush stroke target, and who knows what the end result may be. I may wind up with My Little Pony in Space ;)
I like the Firefly styled concept and I love the idea of some decent "things that man wasn't meant to know" horror mixed in with it. Add in the idea that such stuff is actually encountered and are possibly supernatural in nature? It all results in a fun filled default setting to me. No idea if it will appeal to others, but I expect the feedback on the blog as it gets worked on will attest to that one way or another.
I'm drawn to the idea of cross trained characters and life events during character generation, so I expect I will draw inspiration from Classic Traveller and Crypts & Things for that.
Damn, and I still need to get back to working on my Swords & Sorcery setting for S&W / C&T.